Application for the prediction of disposition and target binding in human for therapeutical antibodies against PD-1 receptor.
A lot of PBPK models describing antibodies are published. There are following differences between InSysBio PBPK model of therapeutic antibodies and published models:
PK/RO simulator for anti-PD-1 mAbs is an application that allows to predict pharmacokinetics (PK) and target binding in human for therapeutic antibodies against PD-1 receptor.
The main objective of the project is a prediction of serum/tumor PK profile of therapeutic mAbs as well as target receptor occupancy in plasma and tumor on the basis of:
The developed minimal PBPK model was successfully tested on the wide panel of anti-PD1 antibodies. Thus, PK/RO simulator may be used as a tool for dose selection of novel antibodies against PD-1 receptor in first-in-human studies.
Contact e-mail: email@example.com
Application development: firstname.lastname@example.org